The pacemaker cells within in the bundle can send electrical pulses at an accelerated rate of 40 to 60 beats per minute. However, the first report of permanent His bundle pacing, by Deshmukh et al., did not occur until 2000. Permanent His-bundle pacing has been gaining popularity in the adult population requiring cardiac resynchronization therapy.Initial procedural challenges are being overcome, and this method of pacing has been shown to improve left ventricular function and heart failure symptoms secondary to ventricular dyssynchrony. [1] The specialized muscle bundle connecting the atrial and ventricular chambers of the heart is now known as the bundle of His. This bundle is located in the interventricular septum that separates the left and right ventricles from each other. His bundle pacing in humans was first described in 1970 by Narula et al. Wilhelm His Jr. described the physical link electrically bridging the atria and ventricles of the heart in 1893. His bundle was explained by ultrastructural and electro-physiologic studies 6 decades later.3,4 By pacing into the His bundle in canine models and human BBB, Scherlag et al5,6 demonstrated normalization of the QRS, thus confirming the concept of longitudinal dissociation. It is characterized by cardiac arrhythmia, or irregular beating of the heart, caused by abnormal conduction from or through the atrioventricular node (AV node). 1 They demonstrated that it was possible to stimulate the His bundle to produce normal physiological ventricular activation via the His-Purkinje system. Anatomical configuration of the His bundle and bundle branches in the human heart. Junctional ectopic tachycardia (JET) is a rare syndrome of the heart that manifests in patients recovering from heart surgery. Methods This is an observational study of patients with HF with typical LBBB who were indicated for pacing therapy and were consecutively enrolled from one centre. The bundle of His connects the AV node to the left and right bundle branches that control the contraction of the ventricles. The relationships among the His bundle, the origin of both bundle branches, and the interventricular (IV) septum were examined histologically in 32 human hearts, and the entire bundle branch systems were delineated in 13 of these. His-bundle pacing in pediatrics and congenital heart disease. We aimed to assess the efficacy of HBP to correct LBBB and long-term clinical outcomes with HBP in patients with heart failure (HF). The His bundle in five hearts traversed the right IV … The bundle of His is the part of the heart's electrical system that controls the beating of the cardiac muscle. He found that these fibres help communicate a single rhythm of contraction to all parts of the heart.